Tiotsetam Influence on Renal Function at Different Mineralocorticoid Activity in the Experiment

Oksana N. Korovenkova, Raisa B. Kosuba, Larusa P. Sidorchuk, Nataliya Ya. Muzyka, Mariia A. Korovenkova

Abstract


Key words: Tiotsetam, kidney function, mineralocorticoid, diuresis.

 

Annotation: for a more complete assessment of the impact Tiotsetam on  water-salt metabolism and kidney function, and determine the effect of a mechanism, shown what Tiotsetam from high mineralocorticoid activity leads to a potentiation of the effect of mineralocorticoids on the kidneys, increasing urine output while increasing natriuresis and an increase in glomerular filtration rate. And Tiotsetam from low mineralocorticoid activity causes a milder diuretic effect, reducing the impact veroshpirona on  excretion salt and without affecting the glomerular filtration.

 


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