Gastroprotective Effect of a Pectin from AMARANTHUS CRUENTUS L

Eleonora I. Khasina


Key words: pectin of Amaranthus cruentus L., gastropathy, indomethacin, meloxicam


Annotation:  This article present an analysis of data protective effect of amaranth pectin from Amaranthus cruenthus L. (fam. Amaranthaceae) in case of indomethacin and meloxicam nonsteroidal anti-flammatory drugs (NSAID)-induced stomach lesions in male Wistar rats. Oral administration of amaranth pectin (100 mg/kg) suppress formation of the gastric mucosal lesions. The findings confirmed that amaranth pectin enhanced resistance of the stomach tissue to NSAIDs and had gastroprotective effect in minimizing the number and sizes of destructive regions, reducing ATP and glycogen deficiency, decreasing excess lactate, and normalizing energy balance in the gastric tissue. Based upon its antiulcer effect, amaranth pectin may be recommended for preventing and treating stomach diseases, combined with the basic therapy.


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