Acute Ischemic Stroke in Patients with Endocrine Disorders

Olena A. Filipets, Oleksandr O. Zhukovskyy


Key words: ischemic stroke, endocrine disorders, diabetes, hypothyroidism.


Annotation: The prevalence of endocrine disorders among patients with ischemic stroke, clinical features of acute stroke in patients with comorbid endocrine pathology, and the impact of diabetes and hypothyroidism on stroke case fatality is studied. Type 2 diabetes significantly increased the risk of case fatality in patients with ischemic stroke and it was associated with increased stroke severity of deep functional deficit.


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Appelros P, Nydevik I, Seiger Å, Terént A. Predictors of severe stroke: influence of preexisting dementia and cardiac disorders. Stroke 2002, 33; 2357-2362.

Banerjee C, Moon YP, Paik MC. Duration of diabetes and risk of ischemic stroke: The Northern Manhattan Study. Stroke 2012, 43; 1212-1217.

Hjalmarsson C, Manhem K, Bokemark L, Andersson B. The role of prestroke glycemic control on severity and outcome of acute ischemic stroke: Stroke Res Treat 2014; 2014: 694569. doi: 10.1155/2014/694569. Epub 2014 Sep 8.

Karakurum GB, Karatas M, Nebioglu A, Tan M, Seydaoglu G, Benli S, Karaca S, Arlier Z, Yerdelen D. Subclinical hypothyroidism, hyperhomocysteinemia and dyslipidemia: investigating links with ischemic stroke in Turkish patients: Neurol Res 2007, 29(8); 871-876.

Kravchenko VI, Postol SV. The dynamics of incidence of thyroid diseases in Ukraine: International Journal of Endocrinology 2011, 3(35); 26-32. (Article in Ukrainian).

Lewis SL. Neurological disorders due to systemic disease: Wiley-Blackwell, Oxford, UK 2013, 1st ed.; 77-106.

Ortega-Casarrubios M, Fuentes B, San Jose B, Martinez P, Diez-Tejedor E. Influence of previous diagnosis of diabetes mellitus in the stroke severity and in-hospital outcome in acute cerebral infarction: Neurologia 2007, 22(7); 426-433.

Pashkovska NV, Pashkovskyy VM. Acute strokes in patients with diabetes mellitus: Praktychna Angiologiya 2011, 5/6; 5-14. (Article in Ukrainian).

Remmel KS, Wanahita A, Moore K, Gruenthal M. Acute ischemic stroke and hypothyroidism. J Ky Med Assoc 2006, 104(5); 191-193.

Sheu JJ, Kang JH, Lin HC. Hyperthyroidism and risk of ischemic stroke in young adults: a 5-year follow-up study. Stroke 2010, 41(5); 961-966.

WHO STEPS Stroke Manual: the WHO STEPwise approach to stroke surveillance, Geneva: World Health Organization, 2006; 96.

Zavaliy LB, Linkov VV, Tochenov MY, Zavaliy YP. Clinical characteristics of stroke in type 2 diabetes: Vrach-Aspirant 2014, 1.1(62); 161-168. (Article in Russian).

Zhang X, Wang F, Zhang Y, Ge Z. Risk factors for developing pneumonia in patients with diabetes mellitus following acute ischaemic stroke: J Int Med Res 2012, 40(5); 1860-1865.