Construction of Plasmid Enriched with Immunostimulatory CpG Motifs
Abstract
The plasmid pCpG-KH11 carrying 104 copies of GTCGTT CpG motif has been constructed. The cloned motif is considered to be the most effective in stimulation of the human immune system. It is suggested that constructed plasmid may be used to improve protein and DNA vaccines and to treat cancer, infectious and allergic diseases.
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